Funding
Extramural Research Funding
Nolan (PI) 04/16/2018 – 03/31/2019
Sponsor: Thrasher Research Fund
Annual DC: $25,000 TC: $25,000
Title: Health evaluation of children with gastrointestinal parasitic-Chagas disease co-infection
Main Goal: We elucidated the influence of co-infection of gastrointestinal parasitic infections and Chagas disease by assessing health indices, cytokine response, and individual’s total parasitic count.
Nolan (MPI), Hotez (PI) 09/01/2017 – 08/31/2021
Sponsor: ExxonMobil Foundation
Annual DC: $100,000 TC: $300,000
Title: Geospatial analysis of high-risk areas for vector-borne transmission utilizing satellite imaging technology
Main Goal: Utilizing the remote sensing techniques currently in use by the oil industry, we propose to develop a new model for identification of mosquito-breeding habitats that pose a risk for human disease transmission.
Nolan (PI) 09/01/2018 – 12/31/2021
Sponsor: The Brockman Medical Research Foundation
Annual DC: $200,959 TC: $883,216
Title: Improving Chagas disease patient diagnosis and health outcomes in the Southwestern United States: Epidemiologic and antigenic characterization of autochthonous cases
Main Goal: The objective of this project is to clarify the risk of locally acquired Trypanosoma cruzi disease transmission and perform epitope mapping of autochthonous parasitic strains in the southwestern US.
Nolan (PI) 09/01/2020 – 12/31/2021
Sponsor: U.S. Department of Health and Human Services (SC DHEC), #NU50CK000542
Annual DC: $499,952 TC: $1,333,934
Title: Epidemiology and laboratory capacity for prevention and control of emerging infectious diseases
Main Goal: This grant defines the baseline COVID-19 immunity in representative South Carolinian populations and characterizes population-specific transmission dynamics. We aim to provide rigorous population immunity projections to inform public health officials’ and policymakers’ decision making.
Nolan (PI) 07/01/2021 – 05/31/2023
Sponsor: US Centers for Disease Control (SC DHEC), #OT21-2103
Annual DC: $1,928,080 TC: $5,480,832
Title: South Carolina’s initiative to address COVID-19 health disparities among populations at high-risk and underserved, including racial and ethnic minority populations and rural communities
Main Goal: This grant develops new lines of public health outreach to communities of Color and performs beta-testing of at-home SARS-CoV-2 surveillance to inform future state public health response.
Nolan (MPI), Gunter (PI) 09/01/2021 – 08/31/2026
Sponsor: National Institutes of Health (NIAID), R01AI165560-01
Annual DC: $499,999 TC: $3,280,171
Title: Next generation mosquito control through technology driven trap development and artificial intelligence guided detection of mosquito breeding habitats
Main Goal: Develop new mosquito control traps and geospatial prediction tools to improve the efficiency of vector control response to Aedes spp mosquitos.
Dinglasan (MPI) – Nolan (Co-PI-Deputy Director) 07/01/2022 – 06/30/2027
Sponsor: U.S. Centers for Disease Control and Prevention, CK000662-01
Annual DC: $2,000,000 TC: $10,000,000
Title: CDC Southeastern Center of Excellence in Vector Borne Diseases: The Gateway Program
Main Goal: This is a renewal application for the CDC Southeastern Center of Excellence in Vector-Borne Diseases: Gateway Program (SECVBD) led by the University of Florida; the goal is to maintain our established, comprehensive, applied, and basic research program to further our understanding of VBD transmission to prevent VBDs in the continental U.S. and territories.
Nolan (PI) 07/13/2022 – 07/12/2023
Sponsor: National Science Foundation, The Extreme Science and Engineering Discovery Environment (XSEDE)
Annual DC: $46,050 TC: $46,050
Title: Aedes Project: a Machine-learning based Aedes Mosquito Egg Identification and Counting system Request
Main Goal: This computational grant provides access to a novel GUI interface called Exosphere for Jetstream2 processing and long-term storage of images for development of an Aedes mosquito egg neural network analysis identification cellphone application.
Nolan (PI) 11/18/2022 – 11/17/2023
Sponsor: South Carolina Department of Health and Environmental Control
Annual DC: $89,996 TC: $89,886
Title: Pathogen surveillance of metastriate ticks in South Carolina
Main Goal: The Nolan lab developed the only validated metastriate tick multiplex bacterial panel digital PCR assay method and will execute this testing approach for informed public health official decision making.
Nolan (PI) 12/01/2022 – 11/30/2023
Sponsor: Burroughs Wellcome Fund, #1023081
Annual DC: $50,000 TC: $50,000
Title: Employing big data methods to elucidate the impact of three decade’s extreme weather events on early childhood development in the United States
Main Goal: This grant employs advanced computational and statistical methods to evaluate the relationship between drought and temperature deviations on USA pediatric population’s development milestones at the neighborhood level.
Intramural Research Funding
Nolan (PI) 04/01/2019 – 08/31/2020
Sponsor: Greenville Health System, Transformative Seed Grant
Annual DC: $20,000 TC: $20,000
Title: Evaluating the clinical and molecular epidemiology of Klebsiella spp infections in the Upstate region of South Carolina
Main Goal: Our study identified antibiotic resistance and associated clinical characteristics of Klebsiella infections within our hospital system and investigated patients with recurrent Klebsiella infections to determine how previous antibiotic exposure has driven antibiotic resistance profiles.
Nolan (PI) 06/01/2020 – 11/30/2020
Sponsor: Prisma Health System, COVID-19 Seed Grant
Annual DC: $16,000 TC: $16,000
Title: SARS-CoV-2 surveillance of asymptomatic pregnant women and comparison of their viral kinetics to symptomatically infected women
Main Goal: This grant will define the testing characteristics of a point-of-care diagnostic for rapid identification of asymptomatically infected women presenting for labor and delivery and compare their viral load decay rate to infected post-partum women with clinically apparent disease.
Nolan (PI) 05/15/2020 – 05/14/2021
Sponsor: University of South Carolina, Office of the Vice-President of Research, COVID-19 Research Initiative
Annual DC: $25,000 TC: $25,000
Title: Clinical, molecular and epidemiological investigations of COVID-19 transmission in the peripartum/postpartum and perinatal/postnatal setting
Main Goal: This grant aims to elucidate the maternal-fetal health outcomes of COVID-19 infection, and the viral kinetics and transmission risk among shared biological samples of mothers and infants.
Nolan (PI) 07/01/2021 – 09/30/2022
Sponsor: University of South Carolina, Office of the Vice-President of Research
Annual DC: $15,000 TC: $15,000
Title: Canine tick-borne disease in South Carolina: Filling in the One Health knowledge gap
Main Goal: This grant will define the risk of canine tickborne disease in South Carolina through strategic vector surveillance, pathogen detection and practicing veterinarian knowledge, attitudes, and practices surveys.
Nolan (PI) 05/01/2022 – 04/30/2023
Sponsor: Prisma Health System Transformative Seed Grant
Annual DC: $20,000 TC: $20,000
Title: Chagas disease seroprevalence among Latinx residents in South Carolina
Main Goal: This serosurvey will assess the prevalence of undiagnosed Chagas disease among patients presenting for clinical care within the Prisma Health system and will generate critical pilot data to inform future Latinx-based clinical education programs to mitigate health disparities.
Nolan (PI) 10/01/2022 – 09/31/2025
Sponsor: South Carolina SmartState Center for Healthcare Quality
Annual DC: $101,267 TC: $303,802
Title: The STICK (Sexually Transmitted Infection Concomitance and Kinetics) Study
Main Goal: This translational investigation aims to advance clinical management of concomitant sexually transmitted infected adolescents and young adults through prospective cohort and pathogenetic investigations.
Nolan (PI) 08/15/2023 – 08/14/2027
Sponsor: University of South Carolina, Office of the Vice-President of Research
Annual DC: $500,000 TC: $2,000,000
Title: University of South Carolina Institute for Infectious Disease Translational Research
Main Goal: This grant will establish an international reputation in infectious disease transdisciplinary research by catalyzing new synergistic collaborations among high-producing faculty and uniting core disciplinary strengths to address key scientific questions that limit our ability to mitigate disease emergence and persistence.